Induction of Apoptosis in Human Breast Adenocarcinoma Cells MCF-7 by Monapurpyridine A, a New Azaphilone Derivative from Monascus purpureus NTU 568

Induction of Apoptosis in Human Breast Adenocarcinoma Cells MCF-7 by Monapurpyridine A, a New Azaphilone Derivative from Monascus purpureus NTU 568

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A new azaphilonidal derivative, monapurpyridine A (MPA), has recently been isolated from the fermented products of Monascus purpureus NTU 568.The structure of MPA was Host-parasite interactions between the piranha Pygocentrus nattereri (Characiformes: Characidae) and isopods and branchiurans (Crustacea) in the rio Araguaia basin, Brazil elucidated by nuclear magnetic resonance (1H-NMR, 13C-NMR, COSY, HMQC, and HMBC) and other spectroscopic analyses.Biological evaluation revealed that MPA could induce cell death in human breast adenocarcinoma cells MCF-7, and it has no significant toxicity to normal mammary epithelial cells M10.The MTT assay and flow cytometric analysis were employed to investigate cell viability and cell cycle influenced by Mapping the impacts of neural networks on human resource management research: a bibliometric analysis MPA.

Moreover, we used Western blot and caspase activity assay to demonstrate the activation of caspase-3, -8 and -9 resulted from MPA.All evidence supported that MPA was suitable for developing into a chemotherapeutic or chemopreventive agent against breast cancer.